The city is making a greater effort to combat the Zika and West Nile viruses.
The Health Department is using trucks to spray pesticide to slow down mosquito breeding around Queens and Staten Island.
Officials say they're targeting areas where they found the type of mosquito that is able carry the viruses.
They emphasize the spraying is preventative and that mosquitoes carrying Zika or West Nile have not been found.
The spraying will take place Thursday night beginning at 10 p.m. and will go until 6 a.m. Friday.
In Queens, parts of College Point, Flushing and Whitestone will be sprayed as well as sections of Annadale, Emerson Hill, and Great Kills on Staten Island.
Officials recommend residents stay indoors during spraying, and bring outdoor equipment and toys inside.