Investigators are working to figure out what caused a fire that tore through a house in Queens and killed five people, including at least two children over the weekend.

Flames broke out Sunday around 2:30 p.m. inside a two-story house located at 112-16 208th Street near 112th Avenue in Queens Village.

The victims have been identified as Chayce Lipford, 2, Rashawn Mattews, 9, Jada Foxworth, 17, Destiny Vicars, 21, and Melody Edwards, 17.

Firee officials say the home, built in 1920, had a wood frame that became quickly engulfed in flames.  

Mayor de Blasio says this is the city's deadliest fire since seven children were killed in a Brooklyn fire in 2015.

"There’s a lot we need to know about what happened here especially the fact that this happened in the middle of a afternoon on a day when the weather was good. How could something like this have happened?" De Blasio said. 

"Everbody was crying. Everybody was screaming. Is any children in there? Is they all out? Is anyone...I mean everybody was so, you know, sympathetic. Everybody, very sympathetic," said one one neighbor.

A man who jumped from the roof to escape the fire was taken to the hospital for his injuries and is expected to recover.

The flames also spread to a house next door, but no one was inside at the time.