Influential women gathered in a sea of red at New York Fashion Week and well-known men all wore blue.
The American Heart Association's Go Red for Women's Red Dress Collection raised awareness of heart disease in women while the Prostate Cancer Foundation's Blue Jacket Fashion Show called attention to prostate cancer.
"I think as a way to make health and well being positive and fun, that combination of fashion and health together is a real winning combination," said American Heart Association CEO Nancy Brown.
The heart association says cardiovascular disease kills one woman in America every 80 seconds, but in many cases it can be prevented. Which is why celebrities like model Kathy Ireland, Tatyana Ali and actress Kate Walsh walked the runway in red.
"It's celebrating women, celebrating life, I think that with any change you have to find the joy and celebration," said Actress Kate Walsh.
One in nine American men can expect to be diagnosed with prostate cancer. Getting checked regulary is the message men in blue jackets like actor Mario Cantone, scientist Bill Nye and TV personality Dr. Mehmet Oz wanted to share.
"The irony is you can prevent it, stop it in it's tracks and live with it if you need to, so if you can get out there and get the word out and raise the money, use the resources that this foundation has done it can change the face of prostate cancer," Oz said.
And it wasn't just celebrities making their way down the catwalk, survivors of these very diseases got their chance to shine.
"I'm a heart transplant survivor, I'd seen the go red collection and I'd always said oh that would be something cool to do someday and here I am, I'm here to spread awareness for a cause that's obviously near and dear to my new heart," said Karen Hill, a heart transplant survivor.
"At the age of 42. I was diagnosed with stage 4 prostate cancer... to be standing here and be amngst you all right now is really a blessing,it's really an amazing thing and sometimes I just think maybe I'm here for a reason," said Todd Seals, a prostate cancer survivor.