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The ASPCA says the 43 dogs were among more than 200 rescued from a mill in Tennessee.

The mills mass produce puppies for the pet store industry, raising them with little to no food or water and poor ventilation, in feces-encrusted pens.

"Most of the animals were in pretty atrocious condition," said Dr. Ellen Hirshberg of the ASPCA.

The dogs have never lived in a normal, caring environment or even seen the outside world, so ASPA officials say the dogs need patient owners who can teach them basic skills.

"They're going to go outside and see a bus and think they're in outer space; they have no idea what's going on," said ASPCA Director Trish McMillan. "Puppy mill dogs are often very difficult to house train because they're not used to being clean. They're used to walking around in their own waste. So you have to take a lot of time, a lot of patience to teach them."

But McMillan says for the right person, the results will make it well worth it.

"It's really rewarding if you take an animal who has never had a good life and you give him a good life," she said. "He's never going to forget it."

All dogs have been treated and vaccinated before being put up for adoption, Friday at the earliest. Those interested can start seeing the dogs as soon as Wednesday.

For more information, go to ASPCA.org or call 212-876-7700 extension 4145.