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It's part of the Metropolitan Transportation Authority's new "Fastrack" program which shuts down entire lines overnight so work can be done faster.

The 4, 5 and 6 lines will be shut down in both directions from 10 p.m. until 5 a.m. between Grand Central Station and Atlantic Avenue in Brooklyn.

In all, 15 stations and an estimated 38,000 subway riders will be affected by the closure.

"I just have to plan better. I just have to think about these changes. I mean, we do it on the weekends anyway," said one subway rider.

"To me I think it's more dangerous to shut it down late-night because it's like if you don't catch a train you have to wait half an hour, 45 minutes for the next one," said another.

As part of the shut down, dozens of workers will be performing some 300 maintenance tasks in stations and tunnels along the track, including signal inspections and power washing.

Depending on location, riders can alternately take the N, Q, R, 2 or 3. Overnight 3 service is being extended into Brooklyn and will make all 4 train stops in Brooklyn.

Some riders who spoke with NY1 say alternatives are often as frustrating as the service changes themselves.

"Alternates don't always help. They're diverting my path, they're taking longer. A commute that could take 10 minutes will take 40 minutes and that's really something that I don't like," said one straphanger.

The last Manhattan-bound train from East 180th Street will be at 9:37 p.m. The last Bronx-bound train from Grand Central will be at 10:26 p.m.

The next "Fastrack" closure will come next month on the Seventh Avenue 1, 2 and 3 lines.

For more information, visit mta.info.