Police Commissioner Ray Kelly said Friday that the police department fears that a missing Manhattan cleaning woman may be dead.

Rodriguez, 46, was last seen on surveillance video at about 7 p.m. on Tuesday, midway through her shift at an office building on Rector Street.

Investigators said the building's cameras never recorded her leaving the building.

Kelly said crews were operating under the premise that something happened inside the office building, and that they were searching for a body in a landfill near Scranton, Pa., where the office building's trash is taken.

"We're not ruling anything out, but that's the theory we are operating under, that something horrid happened to Ms. Rodriguez inside the building," said Kelly.

Rodriguez's purse and street clothes were found in her locker. Her cleaning cart was found abandoned on the eighth floor of the 26-story building.

Rodriguez has a husband and three children in Inwood, Manhattan. Her family is offering a $10,000 reward for information leading to Rodriguez's whereabouts.

"Something happened to her in this building and somebody that knew her or somebody that has been there knows something," said Victor Martinez, the victim's brother.

"I hope she's still alive, which I know she is, and the person that has her to let her go, so she can come back home," said Yaniris Figueroa, the victim's 17-year-old daughter.

Figueroa said that her mother told her recently that she was feeling uneasy at work.

"In the year and a half that she has been working there, [there was] nothing strange until she was seeing a guy was staring at her. So she felt uncomfortable," said Figueroa.

Officials at Stellar Management, which runs the building, refused to comment.

Anyone with information on the case should contact the Crime Stoppers hotline at 1-800-577-TIPS, or text CRIMES and then enter TIP577, or visit www.nypdcrimestoppers.com.