The City Planning Commission certified a proposal to add 240,000-square-feet of office space and a 90,000-square-feet hotel to the historic Chelsea Market building on Ninth Avenue.
The certification means the seven-month-long review and approval process can begin.
Jamestown Properties, which owns the market, says the plan would generate an additional $7 million in property taxes for the city.
The proposal also calls for a $19 million donation to the city for the High Line and would create restrooms and a freight elevator in the market for use by the High Line.
Opponents of the expansion plan say the move would destroy the character of the building and neighborhood.
The first of the public hearings is set for April 16.
NY1 studios are located inside Chelsea Market.