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Statistics show that more than half the US population seems to agree there is nothing like a cup of coffee, or two, or four to get through the day.

"I like that it wakes me up. I'll have it in the morning, afternoon, and sometimes at night," said coffee drinker LIz Botti.

"It definitely makes you feel much peppier and more willing to do the tasks you have to do during the day," said coffee drinker Sara Clemente.

Perhaps beating any drink special for ladies, a new study suggests that coffee fix might give women more than a temporary boost. Women who drank four cups or more a day over a long period of time had a 20 percent lower risk of depression.

"There may be something in coffee that makes the body feel better or give you an endorphin or what they call neurotransmitter that's improved in the body," said New York Presbyterian Columbia Internist Dr. Seth Feltheimer.

While the study suggests there may be some protective benefit this may be another one of those reports you have to take with a grain of salt instead of a lump of sugar.

"It is always hard to take any results like this as being absolutely proven because these types of associative studies are quite interesting in terms of perhaps pointing to an interesting association but sometimes those tend to be wrong when people tend to do more careful prospective studies," said Mood and Anxiety Disorders Program Director at Mt. Sinai Medical Center Dr. Dan Iosifescu.

While numerous other studies are linked to other health benefits from perhaps lower stroke risk in women to cutting diabetes, Parkinson's disease, and Alzheimer's risk in both sexes, there are also negative side effects from interfering with a good night's sleep to impacting blood pressure -- not good if you already have diabetes or heart disease. And doctors say if you are having issues with depression the adrenaline response to caffeinated coffee is likely to make you feel more anxious in the short term.

"There is a chicken and the egg point of view on all of this. What comes first the depression or coffee reversing the depression that is there? I would say does it make me want to drink a cup of coffee in the morning? If I drink a cup of coffee in the morning it is not because of depression. It's because I want to wake up," Feltheimer said.

Before relying on that strong cup for long term benefits, doctors agree more strong research is also needed.