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She launched her inaugural collection at Saks 5th Avenue in 2004, and earlier this month, opened her first boutique in SoHo.

"I was inspired by Versace," she said. "He made women look so sexy. I used to only dream about wearing Versace; I couldn't try it on. So now I can come here and give women clothing they can try on. You can come in here and try on a designer jean."

From designer jeans to trendy tunics to sassy dresses, Zeichner creates fashionable threads in sizes 12-24, reaching a customer a growing number of retailers no longer ignore.

Lauren Sherman of Forbes.com says the plus-size market is making a sizeable cut in the women's apparel industry.

"It's an $18 billion industry, according to research group NPD, and the entire women's market is $88 billion," said Sherman.

With 12 the average size of the American woman, some say 14, there is plenty of room in the plus-size market.

Less than a month into opening her first shop, Zeichner is already looking to expand. She hopes to roll out 40 stores across the country over the next four years.

She says her investors see the potential.

"They have seen the amount of people that come; the excitement that people have," said Zeichner. "They are buying the product. The cash register is ringing."

Even though overall retail sales may be flat, the plus-size woman, finally seeing what she likes at clothing stores, is opening her pocketbook.

"If a woman is size 16 and she hasn't really had the opportunity to buy fashionable clothes for most of her life, she is still going to take the extra time and put in that little extra money, if she has it, to buy things," said Sherman.