State Health Commissioner Dr. Nirav Shah is planning on resigning at the end of June.
A state Department of Health spokesperson told NY1 that the move has been in the works for a number of weeks.
Shah will become the chief operating officer for clinical operations at Kaiser Foundation Health Plan in southern California.
Shah became the state's 15th health commissioner in 2011.
The state Department of Health said First Deputy Commissioner Dr. Howard Zucker will serve as interim commissioner.