Cardinal Timothy Dolan on Thursday offered his prayers for those impacted by the tragedy in East Harlem, including the emergency workers who remain on the scene.
He asked for God's blessing during a service at St. Patrick's Cathedral to celebrate the anniversary of the election of Pope Francis as the head the Catholic church.
The Cathedral is currently undergoing refurbishing, and Dolan likened the situation to the Catholic Church, under the pope's leadership.
"The enormative experience of the life of Francis is when Jesus spoke to him from the cross and said, 'Francis, rebuild my church', and Pope Francis is doing that. And this is a little icon or a symbol of a church with a small 'c' that we're trying to restore and rebuild, but Francis wants to do it with a capital 'C', and I think he's doing it,' Dolan said.
Dolan was joined for the mass by Cardinals from other parts of the country, who praised Pope Francis for "taking the world by storm."
Meanwhile, Pope Francis himself marked the anniversary by tweeting his followers "Please Pray for Me".
He is currently on retreat in the south of Rome.
The Vatican says nothing special is planned other than prayer and meditation.
Francis has won praise around the world for his humble lifestyle, and his focus on mercy rather than moralizing.
But some of his comments -- especially regarding gays and the church -- have drawn concern from more conservative Catholics.
They believe the Pope's actions confuse the faithful and undermine traditional church teaching.
Pope Francis has a busy second year ahead.
He's expected to visit the Holy Land in May and South Korea in August.