City officials and community members unveiled a sign Friday marking Rafael Tufiño Way, which can now be seen along a portion of 103rd Street.
Tufiño is often called the "Painter of the People" for his depictions of daily life in Puerto Rico.
Art lovers who spoke with NY1 say the co-naming is a reminder of his impact on his native culture in the city and abroad.
"It's a way of us in East Harlem to thank him for his contributions and to be able to memorialize his prolific contributions and talent," said City Councilwoman Melissa Mark-Viverito.
"It's a good way of keeping that bridge between the two cultures and the two communities: The Puerto Rican community in Puerto Rico and the Puerto Rican community in the city," said Tufiño's son, Pablo Tufiño.
Tufiño passed away in 2008.
He was one of the founders of El Museo del Barrio in Spanish Harlem.