Police are hoping new forensic tests will cast light on the 2004 murder of Sarah Fox.
Investigators tell the Daily News that a series of tips has led them to two new people of interest.
Their DNA is being tested against clothing found at the scene believed to have belonged to the murdered Juilliard student.
Fox, 21, was found strangled to death in Inwood Hill Park in Upper Manhattan, six days after disappearing while jogging there.
The two people of interest have already been questioned and deny any involvement.
Fox's murder remains an open case.
A long-time person of interest has never been arrested or charged.