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It was a defining moment for a 42-year-old Republican Congressman from Wisconsin.

"I accept the duty to help lead our nation out of a jobs crisis and back to prosperity," Paul Ryan said during his speech at the Republican National Convention Wednesday night.

Republican Presidential candidate Mitt Romney tapped Ryan to be his running mate less than three weeks ago. He is best known in Washington for his proposals to cut federal spending and overhaul Medicare.

"With all their attack ads, the president is just throwing away money," Ryan said. "And he is pretty experienced at that."

Ryan hammered the president on the economy and his health care reform law.

"Obamacare comes to more than 2,000 pages of rules, mandates, taxes, fees and fines that have no place in a free country," Ryan said.

Ryan's selection revved up conservatives. He had no trouble pumping up the crowd at the convention.

"These past four years, we have suffered no shortage of words in the White House," he said. "What's missing is leadership in the White House."

The speech was an opportunity for Ryan to introduce himself to a broader audience. He even managed to poke a little fun at Romney along the way.

"There are songs on his iPod which I've heard on the campaign bus and on many hotel elevators," Ryan said.

And he tried to move beyond all the attention his own budget plans have received to focus on the plans he and Romney have for the country.

"We can get this country working again," he said. "We can get this economy growing again. We can make the safety net safe again."

It's a big to-do list for the Republican ticket.